Biogenesis of Citrinin
نویسندگان
چکیده
منابع مشابه
Biogenesis of citrinin.
The occurrence o. a transfer of the methyl group of methionine to carbon atom 28 of the sterol skeleton was demonstrated in the case of ergosterol biosynthesis in yeast (1, 2). It seemed advisable to investigate another example of this new biological reaction, and the mold metabolite citrinin (Formula I), C&H1405, first described by Hetherington and Raistrick (3), was chosen for this investigat...
متن کاملToxicological properties of citrinin.
Citrinin (CTN) is a nephrotoxic mycotoxin produced by several fungal strains belonging to the genera Penicillium, Aspergillus, and Monascus. It contaminates various commodities of plant origin, cereals in particular, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A (OTA). These two mycotoxins are believed to be involved in the aetiology of endemic nephropathy. In a...
متن کاملAction of citrinin on liposomes.
Citrinin, a mycotoxin, was studied for its effect on artificial membranes (liposomes). Of the three (net positive, negative and neural) liposomal preparations tested, the membrane carrying a net positive charge was preferentially acted upon by citrinin and in this case even the lowest concentration was found to be sufficient for causing a high degree of damage. This is the first report of evide...
متن کاملInteraction of Citrinin with Human Serum Albumin
Citrinin (CIT) is a mycotoxin produced by several Aspergillus, Penicillium, and Monascus species. CIT occurs worldwide in different foods and drinks and causes health problems for humans and animals. Human serum albumin (HSA) is the most abundant plasma protein in human circulation. Albumin forms stable complexes with many drugs and xenobiotics; therefore, HSA commonly plays important role in t...
متن کاملA major decomposition product, citrinin H2, from citrinin on heating with moisture.
Citrinin is one of the mycotoxins produced by Penicillium citrinum. We examined the decomposition products after heating citrinin in water at 140 degrees C and isolated a major product, citrinin H2 (3-(3,5-dihydroxy-2-methylphenyl)-2-formyloxy-butane). Citrinin H2 did not show significant cytotoxicity to HeLa cells up to a concentration of 200 microg/ml (% cytotoxicity: 39%) in 63 h of incubati...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1958
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)77370-0